Acetylcholinesterase

BE0000426ProteinHumansACHE

Hydrolyzes rapidly the acetylcholine neurotransmitter released into the synaptic cleft allowing to terminate the signal transduction at the neuromuscular junction. It is acted on by 162 drugs in DrugBank.

Gene name
ACHE
UniProtKB entry
P22303Swiss-Prot
Cellular location
Synapse
Residues / weight
614 residues · 67,796 Da
Also known as
3.1.1.7 · AChE

Resolves to

Protein
UniProtP22303UniProt nameACES_HUMAN
Gene
HGNCHGNC:108NCBI Gene43GenBank177975GeneCardsACHE
Pharmacology
IUPHAR/GtoPdb2465KEGGhsa:43
Structure
PDB1B41PDB1F8UPDB1VZJ
Drugs

What you can answer from here — as of September 07, 2019

162DrugsApproved to experimental, with action, bond type and pharmacological action
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12Clinical trialsTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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455+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Acetylcholinesterase, how selective are they, and which programs against it are still in active trials?

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