Structure and expression of the human calcitonin/CGRP genes.
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Steenbergh PH, Hoppener JW, Zandberg J, Visser A, Lips CJ, Jansz HS
Structure and expression of the human calcitonin/CGRP genes.
FEBS Lett. 1986 Dec 1;209(1):97-103.
- PubMed ID
- 3492393 [ View in PubMed]
- Abstract
Recently, we have reported the isolation of cDNA encoding a second human calcitonin gene-related peptide (hCGRP-II) [(1985) FEBS Lett. 183, 403-407]. In this report we describe the isolation and characterization of the gene encoding hCGRP-II. This gene, designated CALC-II, is structurally closely related to the known CALC-I gene encoding human calcitonin (hCT) and hCGRP-I. In contrast to CALC-I, CALC-II does not seem to be alternatively expressed. The formation of a second, hCT-like mRNA by differential splicing of CALC-II transcripts is unlikely in view of the structure of CALC-II, and could not be demonstrated in tissues known to express CALC-I and CALC-II.