A second human calcitonin/CGRP gene.

Article Details


Steenbergh PH, Hoppener JW, Zandberg J, Lips CJ, Jansz HS

A second human calcitonin/CGRP gene.

FEBS Lett. 1985 Apr 22;183(2):403-7.

PubMed ID
2985435 [ View in PubMed

The calcitonin (CT) gene is alternatively expressed in a tissue-specific fashion producing either the calcium regulatory hormone CT in the thyroid or the neuropeptide calcitonin gene related peptide (CGRP) in the brain. In medullary carcinoma of the thyroid both peptides are produced. We present here evidence for the existence in the human genome of a second CT gene, which is also expressed in human medullary thyroid carcinoma. This gene encodes a second human CGRP, differing from the known human CGRP in 3 of the 37 amino acids.

DrugBank Data that Cites this Article

NameUniProt ID
Calcitonin gene-related peptide 2P10092Details