Pharmacological and clinical profile of moexipril: a concise review.

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Chrysant SG, Chrysant GS

Pharmacological and clinical profile of moexipril: a concise review.

J Clin Pharmacol. 2004 Aug;44(8):827-36.

PubMed ID

15286086 [ View in PubMed

]

Abstract

Angiotensin-converting enzyme (ACE) inhibitors are effective and safe antihypertensive drugs, with the exception of the rare occasion of angioedema. These drugs have demonstrated additional cardiovascular protective effects to their blood pressure lowering, and their combination with the diuretic hydrochlorothiazide potentiates their antihypertensive effectiveness. Moexipril is a long-acting ACE inhibitor suitable for once-daily administration, and like some ACE inhibitors, moexipril is a prodrug and needs to be hydrolyzed in the liver into its active carboxylic metabolite, moexiprilat, to become effective. Moexipril alone and in combination with low-dose hydrochlorothiazide has been shown in clinical trials to be effective in lowering blood pressure and be well tolerated and safe given in single daily doses. In this review, the pharmacological profile of this drug and its clinical usefulness are discussed.

DrugBank Data that Cites this Article

Drugs

Moexipril

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Moexipril	Angiotensin-converting enzyme	Protein	Humans	Yes	Inhibitor	Details