Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand.
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de Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang WJ, et al.
Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand.
Nature. 1994 Jun 16;369(6481):533-8.
- PubMed ID
- 8202154 [ View in PubMed]
- Abstract
Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic cells. A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified and cloned. This protein binds to and activates the c-mpl protein, a member of the cytokine receptor superfamily. The isolated Mpl ligand shares homology with erythropoietin and stimulates both megakaryocytopoiesis and thrombopoiesis.