Cloning and characterization of the human megakaryocyte growth and development factor (MGDF) gene.
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Chang MS, McNinch J, Basu R, Shutter J, Hsu RY, Perkins C, Mar V, Suggs S, Welcher A, Li L, et al.
Cloning and characterization of the human megakaryocyte growth and development factor (MGDF) gene.
J Biol Chem. 1995 Jan 13;270(2):511-4.
- PubMed ID
- 7822271 [ View in PubMed]
- Abstract
The megakaryocyte growth and development factor (MGDF) is a cytokine that regulates megakaryocyte development and is a ligand for the MPL receptor. In this study, we describe the genomic structure of the human MGDF gene. The MGDF gene was found to consist of seven exons and six introns spanning 8 kilobases. The protein is encoded by exons 3 through 7. The human MGDF gene has been mapped to chromosome 3q26.3. In addition to the previously described full-length cDNA, two cDNA variants were isolated from human fetal liver. Comparison of these two cDNA sequences with the genomic sequence indicates that they arise by differential splicing.