The interaction of metal ions and Marimastat with matrix metalloproteinase 9.

Article Details

Citation

Copy to clipboard

Underwood CK, Min D, Lyons JG, Hambley TW

The interaction of metal ions and Marimastat with matrix metalloproteinase 9.

J Inorg Biochem. 2003 Jun 1;95(2-3):165-70.

PubMed ID

12763661 [ View in PubMed

]

Abstract

The effect of a range of metal ions on the ability of Marimastat to inhibit matrix metalloproteinase 9 (MMP-9) was examined in a fluorescence based proteolytic assay. Whilst none of the metals examined significantly affected the inhibitory ability of Marimastat, several metal ions did have a significant effect on MMP-9 activity itself. In the absence of Marimastat, Zn(II) and Fe(II) significantly inhibited MMP-9 activity at metal ion concentrations of 10 and 100 microM, respectively. In both the absence and presence of Marimastat, Cd(II) significantly inhibited MMP-9 at 100 microM. In contrast, 1 mM Co(II) significantly upregulated MMP-9 proteolytic activity.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Marimastat	Matrix metalloproteinase-9	Protein	Humans	Yes	Inhibitor	Details