Fungal biotransformation of the antihistamine azatadine by Cunninghamella elegans.

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Zhang D, Hansen EB Jr, Deck J, Heinze TM, Sutherland JB, Cerniglia CE

Fungal biotransformation of the antihistamine azatadine by Cunninghamella elegans.

Appl Environ Microbiol. 1996 Sep;62(9):3477-9.

PubMed ID
8795241 [ View in PubMed
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Abstract

The metabolism of the antihistamine azatadine by the zygomycete fungus Cunninghamella elegans ATCC 9245 was investigated. Within 72 h from the addition of the drug to 48-h-old cultures grown in Sabouraud dextrose broth, 95% of azatadine was biotransformed. Two major metabolites, 7-hydroxyazatadine (25%) and 8-hydroxyazatadine (50%), and two minor metabolites, N-desmethylazatadine and 9-hydroxyazatadine, were isolated by high-performance liquid chromatography and characterized by mass spectrometric and proton nuclear magnetic resonance spectroscopic analyses.

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