MutLalpha: at the cutting edge of mismatch repair.
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Jiricny J
MutLalpha: at the cutting edge of mismatch repair.
Cell. 2006 Jul 28;126(2):239-41.
- PubMed ID
- 16873053 [ View in PubMed]
- Abstract
The mismatch repair process corrects errors in newly synthesized DNA. In this issue, Modrich and colleagues (Kadyrov et al., 2006) show that a component of the human mismatch repair machinery, MutLalpha, has endonuclease activity. MutLalpha introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXOI to degrade the strand containing the mismatch.