Effects of levocabastine on lipid mediator release from guinea pig lung fragments.
Article Details
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Sugimoto Y, Iba Y, Ishizawa K, Suzuki G, Kamei C
Effects of levocabastine on lipid mediator release from guinea pig lung fragments.
Acta Med Okayama. 1999 Dec;53(6):271-4.
- PubMed ID
- 10631382 [ View in PubMed]
- Abstract
The effects of levocabastine, a novel histamine H1-receptor antagonist, on lipid mediator release induced by antigen-antibody reaction from actively sensitized guinea pig lung fragments were studied. Levocabastine dose-dependently inhibited the release of leukotriene C4 from guinea pig lung fragments induced by antigen. A significant effect was observed with levocabastine at a concentration of 10(-4) M. On the other hand, levocabastine produced no effect on the release of leukotriene E4 or thromoboxane B2. From these findings, it was concluded that levocabastine may be useful for relieving the nasal obstruction in allergic rhinitis caused by inhibition of leukotriene C4 release.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Levocabastine Histamine H1 receptor Protein Humans YesAntagonistDetails