Three-dimensional structure of the free radical protein of ribonucleotide reductase.
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Nordlund P, Sjoberg BM, Eklund H
Three-dimensional structure of the free radical protein of ribonucleotide reductase.
Nature. 1990 Jun 14;345(6276):593-8.
- PubMed ID
- 2190093 [ View in PubMed]
- Abstract
The enzyme ribonucleotide reductase furnishes precursors for the DNA synthesis of all living cells. One of its constituents, the free radical protein, has an unusual alpha-helical structure. There are two iron centres that are about 25 A apart in the dimeric molecule. Tyrosine 122, which harbours the stable free radical necessary for the activity of ribonucleotide reductase, is buried inside the protein and is located 5 A from the closest iron atom.