Retapamulin inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells.

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Champney WS, Rodgers WK

Retapamulin inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells.

Antimicrob Agents Chemother. 2007 Sep;51(9):3385-7. Epub 2007 Jun 11.

PubMed ID

17562806 [ View in PubMed

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Abstract

Retapamulin inhibited protein biosynthesis and cell viability in methicillin-sensitive and methicillin-resistant Staphylococcus aureus organisms. A specific inhibitory effect on 50S ribosomal subunit formation was also found. Pulse-chase labeling experiments confirmed the specific inhibition of 50S subunit biogenesis. Turnover of 23S rRNA was found, with no effect on 16S rRNA amounts.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Retapamulin	50S ribosomal protein L3	Protein	Streptococcus pyogenes serotype M1	Yes	Inhibitor	Details