Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen.

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Citation

Yano JK, Hsu MH, Griffin KJ, Stout CD, Johnson EF

Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen.

Nat Struct Mol Biol. 2005 Sep;12(9):822-3. Epub 2005 Aug 7.

PubMed ID
16086027 [ View in PubMed
]
Abstract

Human microsomal cytochrome P450 2A6 (CYP2A6) contributes extensively to nicotine detoxication but also activates tobacco-specific procarcinogens to mutagenic products. The CYP2A6 structure shows a compact, hydrophobic active site with one hydrogen bond donor, Asn297, that orients coumarin for regioselective oxidation. The inhibitor methoxsalen effectively fills the active site cavity without substantially perturbing the structure. The structure should aid the design of inhibitors to reduce smoking and tobacco-related cancers.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Cytochrome P450 2A6P11509Details