MRP14 (S100A9) protein interacts with Alzheimer beta-amyloid peptide and induces its fibrillization.
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Zhang C, Liu Y, Gilthorpe J, van der Maarel JR
MRP14 (S100A9) protein interacts with Alzheimer beta-amyloid peptide and induces its fibrillization.
PLoS One. 2012;7(3):e32953. doi: 10.1371/journal.pone.0032953. Epub 2012 Mar 22.
- PubMed ID
- 22457725 [ View in PubMed]
- Abstract
Increasing evidence supports the contribution of local inflammation to the development of Alzheimer's disease (AD) pathology, although the precise mechanisms are not clear. In this study, we demonstrate that the pro-inflammatory protein S100A9 interacts with the Abeta1-40 peptide and promotes the formation of fibrillar beta-amyloid structures. This interaction also results in reduced S100A9 cytotoxicity by the binding of S100A9 toxic species to Abeta1-40 amyloid structures. These results suggest that secretion of S100A9 during inflammation promotes the formation of amyloid plaques. By acting as a sink for toxic species, plaque formation may be the result of a protective response within the brain of AD patients, in part mediated by S100A9.