Emerging roles of PDGF-D signaling pathway in tumor development and progression.
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Wang Z, Ahmad A, Li Y, Kong D, Azmi AS, Banerjee S, Sarkar FH
Emerging roles of PDGF-D signaling pathway in tumor development and progression.
Biochim Biophys Acta. 2010 Aug;1806(1):122-30. doi: 10.1016/j.bbcan.2010.04.003. Epub 2010 Apr 28.
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- 20434526 [ View in PubMed]
- Abstract
Platelet-derived growth factor-D (PDGF-D) can regulate many cellular processes, including cell proliferation, apoptosis, transformation, migration, invasion, angiogenesis and metastasis. Therefore PDGF-D signaling has been considered to be important in human malignancies, and thus PDGF-D signaling may represent a novel therapeutic target, and as such suggests that the development of agents that will target PDGF-D signaling is likely to have a significant therapeutic impact on human cancers. This mini-review describes the mechanisms of signal transduction associated with PDGF-D signaling to support the role of PDGF-D in the carcinogenesis. Moreover, we summarize data on several PDGF-D inhibitors especially naturally occurring "chemopreventive agent" such an indole compound, which we believe could serve as a novel agent for the prevention of tumor progression and/or treatment of human malignancies by targeted inactivation of PDGF-D signaling.