Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein.

Article Details

Citation

Ray RB, Lagging LM, Meyer K, Steele R, Ray R

Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein.

Virus Res. 1995 Aug;37(3):209-20.

PubMed ID
8533458 [ View in PubMed
]
Abstract

The genomic region encoding the hepatitis C virus (HCV) core protein was cloned into a mammalian expression vector to study its role on the transcriptional regulation of cellular proto-oncogene and viral promoters. Using a transient transfection assay in human hepatocellular carcinoma (HepG2) cells, we demonstrate that the HCV core protein activates the human c-myc, Rous sarcoma virus long terminal repeat (LTR), and simian virus 40 (SV40) early promoters; and suppresses the c-fos promoter and human immunodeficiency virus type 1 (HIV-1) LTR activity. The transcriptional regulation of cellular proto-oncogenes by the HCV core protein suggests possible involvement of the core protein in the deregulation of normal hepatocyte growth and hepatocarcinogenesis.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Genome polyproteinP26664Details