Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein.

Article Details

Citation

Taylor DR, Shi ST, Romano PR, Barber GN, Lai MM

Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein.

Science. 1999 Jul 2;285(5424):107-10.

PubMed ID
10390359 [ View in PubMed
]
Abstract

Most isolates of hepatitis C virus (HCV) infections are resistant to interferon, the only available therapy, but the mechanism underlying this resistance has not been defined. Here it is shown that the HCV envelope protein E2 contains a sequence identical with phosphorylation sites of the interferon-inducible protein kinase PKR and the translation initiation factor eIF2alpha, a target of PKR. E2 inhibited the kinase activity of PKR and blocked its inhibitory effect on protein synthesis and cell growth. This interaction of E2 and PKR may be one mechanism by which HCV circumvents the antiviral effect of interferon.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Genome polyproteinP26664Details
Interferon-induced, double-stranded RNA-activated protein kinaseP19525Details