The genetic variation of the human HMGB1 gene.

Article Details

Citation

Kornblit B, Munthe-Fog L, Petersen SL, Madsen HO, Vindelov L, Garred P

The genetic variation of the human HMGB1 gene.

Tissue Antigens. 2007 Aug;70(2):151-6.

PubMed ID
17610420 [ View in PubMed
]
Abstract

High-mobility group box 1 protein (HMGB1) is a nuclear DNA-binding protein, which also functions as a pleiotropic cytokine, implicated in the pathology of several different immune-mediated diseases. The purpose of this study was to examine the HMGB1 gene for putative polymorphisms in 103 healthy Caucasian Danish blood donors. A total of six polymorphisms and four mutations were identified in the HMGB1 gene. Subsequent MatInspector estimation revealed that several polymorphisms might have a potential regulatory impact on HMGB1 transcription. This study has characterized genetic variations in the HMGB1 gene locus, which may have a regulating role in the expression of HMGB1, providing the basis for molecular investigations of the HMGB1 gene in different disease settings.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
High mobility group protein B1P09429Details