The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases.
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Chen Y, Tian Q
The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases.
Front Med. 2011 Mar;5(1):70-6. doi: 10.1007/s11684-011-0119-9. Epub 2011 Mar 17.
- PubMed ID
- 21681677 [ View in PubMed]
- Abstract
Protein kinase C epsilon (PKC varepsilon) is one of major isoforms in novel PKC family. Although it has been extensively characterized in the past decade, the role of PKC varepsilon in neuron is still not well understood. Advances in molecular biology have now removed significant barriers to the direct investigation of PKC varepsilon functions in vivo, and PKC varepsilon has been increasingly implicated in the neural biological functions and associated neurogenic diseases. Recent studies have provided important insights into the influence of PKC varepsilon on cortical processing at both the single cell level and network level. These studies provide compelling evidence that PKC varepsilon could regulate distinct aspects of neural signal transduction and suggest that the coordinated actions of a number of molecular signals contribute to the specification and differentiation of PKC varepsilon signal pathway in the developing brain.