Multiple independent molecular etiology for limb-girdle muscular dystrophy type 2A patients from various geographical origins.

Article Details

Citation

Richard I, Brenguier L, Dincer P, Roudaut C, Bady B, Burgunder JM, Chemaly R, Garcia CA, Halaby G, Jackson CE, Kurnit DM, Lefranc G, Legum C, Loiselet J, Merlini L, Nivelon-Chevallier A, Ollagnon-Roman E, Restagno G, Topaloglu H, Beckmann JS

Multiple independent molecular etiology for limb-girdle muscular dystrophy type 2A patients from various geographical origins.

Am J Hum Genet. 1997 May;60(5):1128-38.

PubMed ID
9150160 [ View in PubMed
]
Abstract

Limb-girdle muscular dystrophies (LGMDs) are a group of neuromuscular diseases presenting great clinical heterogeneity. Mutations in CANP3, the gene encoding muscle-specific calpain, were used to identify this gene as the genetic site responsible for autosomal recessive LGMD type 2A (LGMD2A; MIM 253600). Analyses of the segregation of markers flanking the LGMD2A locus and a search for CANP3 mutations were performed for 21 LGMD2 pedigrees from various origins. In addition to the 16 mutations described previously, we report 19 novel mutations. These data indicate that muscular dystrophy caused by mutations in CANP3 are found in patients from all countries examined so far and further support the wide heterogeneity of molecular defects in this rare disease.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Calpain-3P20807Details