CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein.
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Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein.
Science. 1990 Sep 21;249(4975):1431-3.
- PubMed ID
- 1698311 [ View in PubMed]
- Abstract
Leukocytes respond to lipopolysaccharide (LPS) at nanogram per milliliter concentrations with secretion of cytokines such as tumor necrosis factor-alpha (TNF-alpha). Excess secretion of TNF-alpha causes endotoxic shock, an often fatal complication of infection. LPS in the bloodstream rapidly binds to the serum protein, lipopolysaccharide binding protein (LBP), and cellular responses to physiological levels of LPS are dependent on LBP. CD14, a differentiation antigen of monocytes, was found to bind complexes of LPS and LBP, and blockade of CD14 with monoclonal antibodies prevented synthesis of TNF-alpha by whole blood incubated with LPS. Thus, LPS may induce responses by interacting with a soluble binding protein in serum that then binds the cell surface protein CD14.