Novel isoform of beta 1 integrin expressed in skeletal and cardiac muscle.
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Zhidkova NI, Belkin AM, Mayne R
Novel isoform of beta 1 integrin expressed in skeletal and cardiac muscle.
Biochem Biophys Res Commun. 1995 Sep 5;214(1):279-85.
- PubMed ID
- 7545396 [ View in PubMed]
- Abstract
We describe a novel isoform of the beta 1 integrin subunit called beta 1D, which contains a unique cytoplasmic domain, and is expressed specifically in skeletal and cardiac muscle. The beta 1D isoform arises from splicing into the final transcript of an additional exon located between exons 6 and 7. The nucleotide sequence of beta 1D predicts a cytoplasmic domain of 50 amino acids in which the last 21 amino acids of the beta 1A integrin isoform are replaced by a related sequence of 24 amino acids. A beta 1D-specific anti-peptide polyclonal antibody was prepared and immunoprecipitation of tissue extracts with subsequent immunoblotting showed expression of beta 1D isoform only in striated muscle cells.