Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2.

Article Details

Citation

Bergelson JM, St John N, Kawaguchi S, Chan M, Stubdal H, Modlin J, Finberg RW

Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2.

J Virol. 1993 Nov;67(11):6847-52.

PubMed ID
8411387 [ View in PubMed
]
Abstract

Anti-VLA-2 antibodies protected HeLa cells from infection by echoviruses 1 and 8 but not from infection by other echovirus serotypes. Echoviruses 1 and 8 bound to and infected nonpermissive hamster cells transfected with the alpha 2 subunit of human VLA-2. These results indicate that the human alpha 2 subunit is critical for infection by echoviruses 1 and 8 but that other echovirus serotypes must bind receptors other than VLA-2.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Integrin beta-1P05556Details
Genome polyproteinO91734Details