Procainamide inhibits DNA methyltransferase in a human T cell line.

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Scheinbart LS, Johnson MA, Gross LA, Edelstein SR, Richardson BC

Procainamide inhibits DNA methyltransferase in a human T cell line.

J Rheumatol. 1991 Apr;18(4):530-4.

PubMed ID

2066944 [ View in PubMed

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Abstract

Procainamide, a widely used antiarrythmic, causes DNA hypomethylation in the human T cell line Jurkat, but the mechanism is unknown. We report that procainamide inhibits the DNA methyltransferase catalyzed transfer of methyl groups from S-adenosylmethionine to DNA, but has no effect on other known regulators of DNA methylation. Our results suggest that procainamide could inhibit cellular DNA methylation by inhibiting DNA methyltransferase activity.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Procainamide	DNA (cytosine-5)-methyltransferase 1	Protein	Humans	Unknown	Other	Details