Efficacies of zinc-finger-active drugs against Giardia lamblia.

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Nash T, Rice WG

Efficacies of zinc-finger-active drugs against Giardia lamblia.

Antimicrob Agents Chemother. 1998 Jun;42(6):1488-92.

PubMed ID
9624499 [ View in PubMed
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Abstract

Twenty-nine of 34 (85%) Zn-finger-active compounds at 300 microM or less inhibited the growth of Giardia lamblia. The most active compound, disulfiram (Antabuse), was cidal at 1.23 +/- 0.32 microM. In the adult mouse model, significant in vivo activity was demonstrated by increased cure rates and decreased parasite burdens.

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