Different expression of the myotonin protein kinase gene in discrete areas of human brain.
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Gennarelli M, Lucarelli M, Zelano G, Pizzuti A, Novelli G, Dallapiccola B
Different expression of the myotonin protein kinase gene in discrete areas of human brain.
Biochem Biophys Res Commun. 1995 Nov 13;216(2):489-94.
- PubMed ID
- 7488138 [ View in PubMed]
- Abstract
We have examined the myotonin protein kinase (MT-PK) gene expression in different human brain areas. Four different spliced forms, comprising exons 13 and 14, were identified and characterized. One form (MYOT-A), lacking the entire exon 13, had not been detected in other studies and it is likely to be a brain-specific transcript. Different brain areas show a specific transcription pattern. These results suggest that MT-PK may have specialized functions in different areas of central nervous system. Alterations of this complex expression pattern could be responsible for the mental status impairment observed in myotonic dystrophy patients.