Emergence of cytomegalovirus disease in patients receiving temozolomide: report of two cases and literature review.

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Meije Y, Lizasoain M, Garcia-Reyne A, Martinez P, Rodriguez V, Lopez-Medrano F, Juan RS, Lalueza A, Aguado JM

Emergence of cytomegalovirus disease in patients receiving temozolomide: report of two cases and literature review.

Clin Infect Dis. 2010 Jun 15;50(12):e73-6. doi: 10.1086/653011.

PubMed ID
20455691 [ View in PubMed
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Abstract

Temozolomide chemotherapy has become part of the therapy used to treat glioblastoma multiforme and refractory anaplastic astrocytoma. Temozolomide frequently produces profound lymphopenia. We report 2 cases of cytomegalovirus disease that occurred in patients receiving temozolomide therapy and review 4 additional cases reported in the literature. Narrow monitoring with cytomegalovirus antigenemia assay should be considered for recommendation.

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