The electronic and serotonin receptor binding affinity properties of N,N-dimethyltryptamine analogs.

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Glennon RA, Gessner PK

The electronic and serotonin receptor binding affinity properties of N,N-dimethyltryptamine analogs.

Res Commun Chem Pathol Pharmacol. 1977 Nov;18(3):453-65.

PubMed ID

270770 [ View in PubMed

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Abstract

The electronic properties of a series of N,N-dimethyltryptamines and related analogs, for which binding affinity data are available, were examined using both a pi-electron and an all-valence electron method. The results suggest that affinity is related to the ability of these compounds to donate electrons in a localized charge transfer manner from the 4-position of the indole nucleus.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Dimethyltryptamine	5-hydroxytryptamine receptor 6	Protein	Humans	Yes	Not Available	Details