Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes.

Article Details

Citation
Copy to clipboard

Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, Schreiber SL

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes.

Cell. 1991 Aug 23;66(4):807-15.

PubMed ID
1715244 [ View in PubMed
]
Abstract

Although the immediate receptors (immunophilins) of the immunosuppressants cyclosporin A (CsA) and FK506 are distinct, their similar mechanisms of inhibition of cell signaling suggest that their associated immunophilin complexes interact with a common target. We report here that the complexes cyclophilin-CsA and FKBP-FK506 (but not cyclophilin, FKBP, FKBP-rapamycin, or FKBP-506BD) competitively bind to and inhibit the Ca(2+)- and calmodulin-dependent phosphatase calcineurin, although the binding and inhibition of calcineurin do not require calmodulin. These results suggest that calcineurin is involved in a common step associated with T cell receptor and IgE receptor signaling pathways and that cyclophilin and FKBP mediate the actions of CsA and FK506, respectively, by forming drug-dependent complexes with and altering the activity of calcineurin-calmodulin.

DrugBank Data that Cites this Article

Drugs