The nucleotide sequence of poliovirus type 3 leon 12 a1b: comparison with poliovirus type 1.
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Stanway G, Cann AJ, Hauptmann R, Hughes P, Clarke LD, Mountford RC, Minor PD, Schild GC, Almond JW
The nucleotide sequence of poliovirus type 3 leon 12 a1b: comparison with poliovirus type 1.
Nucleic Acids Res. 1983 Aug 25;11(16):5629-43.
- PubMed ID
- 6310508 [ View in PubMed]
- Abstract
The complete nucleotide sequence of the genome of the Sabin vaccine strain of poliovirus type 3 (P3/Leon 12 a1 b) has been determined from cDNA cloned in E. coli. The genome comprises a 5' non-coding region of 742 nucleotides, a large open reading frame of 6618 nucleotides (89% of the sequence) and a 3' non-coding region of 72 nucleotides. There is 77.4% base-sequence homology and 89.6% predicted amino-acid homology between types 1 and 3. Conservation of all glutamine-glycine and tyrosine-glycine cleavage sites suggests a mechanism of polyprotein processing similar to that established for poliovirus type 1.