Psammaplin A, a chitinase inhibitor isolated from the Fijian marine sponge Aplysinella rhax.
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Tabudravu JN, Eijsink VG, Gooday GW, Jaspars M, Komander D, Legg M, Synstad B, van Aalten DM
Psammaplin A, a chitinase inhibitor isolated from the Fijian marine sponge Aplysinella rhax.
Bioorg Med Chem. 2002 Apr;10(4):1123-8.
- PubMed ID
- 11836123 [ View in PubMed]
- Abstract
Several brominated tyrosine derived compounds, psammaplins A (1), K (2) and L (3) as well as bisaprasin (4) were isolated from the Fijian marine sponge Aplysinella rhax during a bioassay guided isolation protocol. Their structures were determined using NMR and MS techniques. Psammaplin A was found to moderately inhibit chitinase B from Serratia marcescens, the mode of inhibition being non-competitive. Crystallographic studies suggest that a disordered psammaplin A molecule is bound near the active site. Interestingly, psammaplin A was found to be a potent antifungal agent.