SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria.
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Onyango P, Celic I, McCaffery JM, Boeke JD, Feinberg AP
SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria.
Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13653-8. Epub 2002 Oct 8.
- PubMed ID
- 12374852 [ View in PubMed]
- Abstract
The SIR2 (silent information regulator 2) gene family has diverse functions in yeast including gene silencing, DNA repair, cell-cycle progression, and chromosome fidelity in meiosis and aging. Human homologues, termed sirtuins, are highly conserved but are of unknown function. We previously identified a large imprinted gene domain on 11p15.5 and investigated the 11p15.5 sirtuin SIRT3. Although this gene was not imprinted, we found that it is localized to mitochondria, with a mitochondrial targeting signal within a unique N-terminal peptide sequence. The encoded protein was found also to possess NAD(+)-dependent histone deacetylase activity. These results suggest a previously unrecognized organelle for sirtuin function and that the role of SIRT3 in mitochondria involves protein deacetylation.