PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.

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Spiegelman BM

PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.

Diabetes. 1998 Apr;47(4):507-14.

PubMed ID

9568680 [ View in PubMed

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Abstract

The past several years have seen an explosive increase in our understanding of the transcriptional basis of adipose cell differentiation. In particular, a key role has been illustrated for PPAR-gamma, a member of the nuclear hormone receptor superfamily. PPAR-gamma has also been recently identified as the major functional receptor for the thiazolidinedione class of insulin-sensitizing drugs. This review examines the evidence that has implicated this transcription factor in the processes of adipogenesis and systemic insulin action. In addition, several models are discussed that may explain how a single protein can be involved in these related but distinct physiological actions. I also point out several important areas where our knowledge is incomplete and more research is needed. Finally, I discuss how advances in our understanding of nuclear receptor function, particularly the docking of cofactors in a ligand-dependent fashion, should lead to improved drugs that utilize the PPAR-gamma system for the treatment of insulin resistance.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Pioglitazone	Peroxisome proliferator-activated receptor gamma	Protein	Humans	Yes	Agonist	Details