A major genotype in UDP-glucuronosyltransferase 2B15.

Article Details


Toide K, Umeda S, Yamazaki H, Takahashi Y, Terauchi Y, Fujii T, Kamataki T

A major genotype in UDP-glucuronosyltransferase 2B15.

Drug Metab Pharmacokinet. 2002;17(2):164-6.

PubMed ID
15618667 [ View in PubMed

A novel single nucleotide polymorphism (SNP) was found in exon 6 of the UDP-glucuronosyltransferase (UGT) 2B15 gene from healthy Japanese populations. The SNP was as follows: SNP, 020228Toide001; GENE NAME, UGT2B15; ACCESSION NUMBER, U08854, AF180322, and NM_001078; LENGTH, 25 base; 5'-AGCTTGCCAAAAC/AAGGAAAGAAGAA-3'. This SNP was expected to cause a change of an amino acid residue at the position 523 (Thr to Lys) located in a putative co-factor binding region. The allele frequency of this SNP was 79% in Japanese, suggesting this polymorphism to be a major genotype in Japanese people.

DrugBank Data that Cites this Article

NameUniProt ID
UDP-glucuronosyltransferase 2B15P54855Details