Vascular endothelial growth factor B, a novel growth factor for endothelial cells.
Article Details
- CitationCopy to clipboard
Olofsson B, Pajusola K, Kaipainen A, von Euler G, Joukov V, Saksela O, Orpana A, Pettersson RF, Alitalo K, Eriksson U
Vascular endothelial growth factor B, a novel growth factor for endothelial cells.
Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2576-81.
- PubMed ID
- 8637916 [ View in PubMed]
- Abstract
We have isolated and characterized a novel growth factor for endothelial cells, vascular endothelial growth factor B (VEGF-B), with structural similarities to vascular endothelial growth factor (VEGF) and placenta growth factor. VEGF-B was particularly abundant in heart and skeletal muscle and was coexpressed with VEGF in these and other tissues. VEGF-B formed cell-surface-associated disulfide-linked homodimers and heterodimerized with VEGF when coexpressed. Conditioned medium from transfected 293EBNA cells expressing VEGF-B stimulated DNA synthesis in endothelial cells. Our results suggest that VEGF-B has a role in angiogenesis and endothelial cell growth, particularly in muscle.