Role of ErbB4 in breast cancer.
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Sundvall M, Iljin K, Kilpinen S, Sara H, Kallioniemi OP, Elenius K
Role of ErbB4 in breast cancer.
J Mammary Gland Biol Neoplasia. 2008 Jun;13(2):259-68. doi: 10.1007/s10911-008-9079-3. Epub 2008 May 3.
- PubMed ID
- 18454307 [ View in PubMed]
- Abstract
Members of the ErbB subfamily of receptor tyrosine kinases are important regulators of normal mammary gland physiology, and aberrations in their signaling have been associated with breast tumorigenesis. Therapeutics targeting epidermal growth factor receptor (EGFR = ErbB1) or ErbB2 in breast cancer have been approved for clinical use. In contrast, relatively little is known about the biological significance of ErbB4 signaling in breast cancer. This review focuses on recent advances in our understanding about the role of ErbB4 in breast carcinogenesis, as well as in the potential clinical relevance of ErbB4 in breast cancer prognostics and therapy.