Effect of amodiaquine on gastric histamine methyltransferase and on histamine-stimulated gastric secretion.

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Barth H, Lorenz W, Troidl H

Effect of amodiaquine on gastric histamine methyltransferase and on histamine-stimulated gastric secretion.

Br J Pharmacol. 1975 Nov;55(3):321-7.

PubMed ID

1203620 [ View in PubMed

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Abstract

1 Amodiaquine was found to be a potent inhibitor in vitro of gastric histamine methyltransferase from human and canine corpus and from pig antrum. The ID50 for the enzyme, purified from pig antrum mucosa by ultracentrifugation and chromatography on DEAE-cellulose, was 2.5 muM. 2 In six dogs with Heidenhanin pouches the maximum secretory response to histamine (40 mug/kg i.m.) was augmented by i.m. injection of amodiaquine. The augmentation depended on the dose of amodiaquine, the optimum effect (40% increase in volume of gastric juice, 80% in acid output) being achieved with 2 mg/kg. The maximum secretory response to betazole was also enhanced by amodiaquine. 3 It was suggested that amodiaquine may enhance the histamine and betazole stimulated gastric secretion by an inhibition of gastric histamine methyltransferase in vivo.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Amodiaquine	Histamine N-methyltransferase	Protein	Humans	Unknown	Inhibitor	Details