Transcriptional regulation of adipocyte differentiation: a central role for CCAAT/enhancer-binding protein (C/EBP) beta.
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Guo L, Li X, Tang QQ
Transcriptional regulation of adipocyte differentiation: a central role for CCAAT/enhancer-binding protein (C/EBP) beta.
J Biol Chem. 2015 Jan 9;290(2):755-61. doi: 10.1074/jbc.R114.619957. Epub 2014 Dec 1.
- PubMed ID
- 25451943 [ View in PubMed]
- Abstract
A detailed understanding of the processes controlling adipogenesis is instrumental in the fight against the obesity epidemic. Adipogenesis is controlled by a transcriptional cascade composed of a large number of transcriptional factors, among which CCAAT/enhancer-binding protein (C/EBP) beta plays an essential role. During 3T3-L1 adipocyte differentiation, C/EBPbeta is induced early to transactivate the expression of C/EBPalpha and peroxisome proliferator-activated receptor gamma (PPARgamma), two master transcription factors for terminal adipocyte differentiation. Studies in recent years have revealed many new target genes of C/EBPbeta, implicating its participation in many other processes during adipogenesis, such as mitotic clonal expansion, epigenetic regulation, unfolded protein response, and autophagy. Moreover, the function of C/EBPbeta is highly regulated by post-translational modifications, which are crucial for the proper activation of the adipogenic program. Advances toward elucidation of the function and roles of the post-translational modification of C/EBPbeta during adipogenesis will greatly improve our understanding of the molecular mechanisms governing adipogenesis.