Use of once-daily netilmicin to treat infants with suspected sepsis in a neonatal intensive care unit.

Article Details

Citation
Copy to clipboard

Brooks JR, Marlow N, Reeves BC, Millar MR

Use of once-daily netilmicin to treat infants with suspected sepsis in a neonatal intensive care unit.

Biol Neonate. 2004;86(3):170-5. Epub 2004 Jun 29.

PubMed ID
15237240 [ View in PubMed
]
Abstract

Once-daily administration of aminoglycoside antibiotics has become the most acceptable dosing schedule for the majority of patients. There are few published data on the impact of post-natal age on aminoglycoside concentrations in preterm infants receiving once-daily dosage regimens. Netilmicin was administered as a once-daily dose of 4 mg/kg. In 141 episodes of suspected sepsis in 123 babies, trough netilmicin concentrations ranged from undetectable to 4.0 mg/l. Netilmicin concentrations were above a level of 2 mg/l in 10.6% of episodes. Netilmicin concentrations decreased with increasing post-natal age and weight. Levels were higher in males compared to females. Increased creatinine concentrations were associated with higher netilmicin concentrations. This study emphasises the importance of post-natal age as a determinant of aminoglycoside concentrations with a once-daily dosing regimen in a neonatal intensive care population. Trough levels should be carefully monitored and consideration given to extending dosage intervals particularly when netilmicin is administered once daily to preterm infants in the first week of life.

DrugBank Data that Cites this Article

Drugs