Triggering the interferon antiviral response through an IKK-related pathway.
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Sharma S, tenOever BR, Grandvaux N, Zhou GP, Lin R, Hiscott J
Triggering the interferon antiviral response through an IKK-related pathway.
Science. 2003 May 16;300(5622):1148-51. Epub 2003 Apr 17.
- PubMed ID
- 12702806 [ View in PubMed]
- Abstract
Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous transcription factors. Although signaling pathways that activate the transcription factors nuclear factor kappaB and ATF-2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3 and IRF-7 has remained a critical missing link in understanding interferon signaling. We report here that the IkappaB kinase (IKK)-related kinases IKKepsilon and TANK-binding kinase 1 are components of the virus-activated kinase that phosphorylate IRF-3 and IRF-7. These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection.