Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.
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Yoshida H, Bogaki M, Nakamura M, Nakamura S
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.
Antimicrob Agents Chemother. 1990 Jun;34(6):1271-2.
- PubMed ID
- 2168148 [ View in PubMed]
- Abstract
Nucleotide sequence analysis of the gyrA genes of 10 spontaneous quinolone-resistant gyrA mutants of Escherichia coli KL16, including four mutants examined previously, disclosed that quinolone resistance was caused by a point mutation within the region between amino acids 67 and 106, especially in the vicinity of amino acid 83, of the GyrA protein.