A malaria protein exported into a new compartment within the host erythrocyte.
Article Details
- CitationCopy to clipboard
Simmons D, Woollett G, Bergin-Cartwright M, Kay D, Scaife J
A malaria protein exported into a new compartment within the host erythrocyte.
EMBO J. 1987 Feb;6(2):485-91.
- PubMed ID
- 2438130 [ View in PubMed]
- Abstract
A Plasmodium falciparum protein which is exported into a new compartment in the host erythrocyte has been located. This protein, exp-1, has a variable region recognized by a monoclonal antibody. Naturally occurring mutants of this region have been characterized. All mutants studied so far have the same A----G transition abolishing the target for the antibody. The exp-1 gene has a complex structure containing two introns. It is highly conserved in five independent, genetically defined parasite lines, suggesting that exp-1 has an important function. We discuss the possible role of exp-1 in P. falciparum infections.