Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines.
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Tarroni P, Rubboli F, Chini B, Zwart R, Oortgiesen M, Sher E, Clementi F
Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines.
FEBS Lett. 1992 Nov 2;312(1):66-70.
- PubMed ID
- 1330682 [ View in PubMed]
- Abstract
A beta subunit of the neuronal nicotinic receptor, sharing 88% homology with the rat beta 4 subunit, has been cloned from a human neuroblastoma cell line. The gene encoding the human beta 4 subunit is expressed in association with the alpha 3 gene in neuroblastoma and small-cell lung carcinoma cell lines. Patch-clamp experiments and radioligand binding assays confirm that these neuroendocrine tumor cell lines express functional neuronal nicotinic receptors. We suggest that these receptors might play a crucial role in the control of neurotransmitter and hormone secretion from neurosecretory human tumors.