Structure, expression profile and chromosomal location of an isolog of DNA-PKcs interacting protein (KIP) gene.
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Seki N, Hattori A, Hayashi A, Kozuma S, Ohira M, Hori T, Saito T
Structure, expression profile and chromosomal location of an isolog of DNA-PKcs interacting protein (KIP) gene.
Biochim Biophys Acta. 1999 Jan 18;1444(1):143-7.
- PubMed ID
- 9931475 [ View in PubMed]
- Abstract
A novel DNA-PKcs interacting protein, KIP (kinase interacting protein), was recently isolated using a two-hybrid analysis which showed a significant homology to calcineurin B. We found other ESTs showing significant similarity to KIP gene in the dbEST database and isolated a cDNA clone which encodes a 187 amino acid polypeptide from a human fetal brain cDNA library. This protein (termed KIP2 for kinase interacting protein 2) has sequence homology to KIP (46% identical and 64% similarity). RT-PCR analysis showed that the messenger RNA was ubiquitously expressed in various human tissues. Based on PCR-based analysis with a radiation hybrid cell panel and fluorescence in situ hybridization, the gene was localized to the q24 region of chromosome 15.