In vitro activity of cefpiramide (SM-1652) against gram-negative bacilli.

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Fass RJ, Helsel VL

In vitro activity of cefpiramide (SM-1652) against gram-negative bacilli.

Diagn Microbiol Infect Dis. 1986 Jan;4(1):77-81.

PubMed ID

3943292 [ View in PubMed

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Abstract

The susceptibilities of 317 gram-negative bacilli to cefpiramide, cefotaxime, and piperacillin were determined by standardized microdilution and disk diffusion tests. Cefpiramide and piperacillin were more consistently active against nonfermenters than against Enterobacteriaceae, whereas cefotaxime was more active against Enterobacteriaceae. Inhibitory zone diameters of approximately 75-micrograms cefpiramide disks correlated well with minimal inhibitory concentrations (r = 0.85); breakpoints for defining susceptibility and resistance were recommended.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Cefpiramide	D-alanyl-D-alanine carboxypeptidase DacC	Protein	Escherichia coli (strain K12)	Yes	Inhibitor	Details
Cefpiramide	Penicillin-binding protein 1A	Protein	Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)	Yes	Inhibitor	Details
Cefpiramide	Penicillin-binding protein 1A	Protein	Escherichia coli (strain K12)	Yes	Inhibitor	Details
Cefpiramide	Penicillin-binding protein 1B	Protein	Escherichia coli (strain K12)	Yes	Inhibitor	Details
Cefpiramide	Penicillin-binding protein 1B	Protein	Pseudomonas aeruginosa	Yes	Inhibitor	Details
Cefpiramide	Peptidoglycan synthase FtsI	Protein	Escherichia coli (strain K12)	Yes	Inhibitor	Details