Complementary DNA cloning of complement C8 beta and its sequence homology to C9.
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Haefliger JA, Tschopp J, Nardelli D, Wahli W, Kocher HP, Tosi M, Stanley KK
Complementary DNA cloning of complement C8 beta and its sequence homology to C9.
Biochemistry. 1987 Jun 16;26(12):3551-6.
- PubMed ID
- 3651397 [ View in PubMed]
- Abstract
The complete amino acid sequence of mature C8 beta has been derived from the DNA sequence of a cDNA clone identified by expression screening of a human liver cDNA library. Comparison with the amino acid sequence of C9 shows an overall homology with few deletions and insertions. In particular, the cysteine-rich domains and membrane-inserting regions of C9 are well conserved. These findings are discussed in relation to a possible mechanism of membrane attack complex formation.