Human complement component C8. Molecular basis of the beta-chain polymorphism.
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Dewald G, Hemmer S, Nothen MM
Human complement component C8. Molecular basis of the beta-chain polymorphism.
FEBS Lett. 1994 Mar 7;340(3):211-5.
- PubMed ID
- 8131848 [ View in PubMed]
- Abstract
The beta-chain of human complement component C8 exhibits a structural genetic polymorphism: using isoelectric focusing two major allotypes can be identified (C8B B ('basic') and C8B A ('acidic')). In the present report we describe a sequence polymorphism of the C8B gene (codon 63: AGA-->GGA) and demonstrate that the resulting amino acid substitution (Arg-->Gly) consistently differentiates between the two common charge variants of the C8 beta chain; the C8B B allotype is characterized by an Arg and the C8B A allotype by a Gly residue in position 63 of the C8 beta polypeptide chain.