Immunoglobulin somatic hypermutation.

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Teng G, Papavasiliou FN

Immunoglobulin somatic hypermutation.

Annu Rev Genet. 2007;41:107-20.

PubMed ID
17576170 [ View in PubMed
]
Abstract

The immunoglobulin (Ig) repertoire achieves functional diversification through several somatic alterations of the Ig locus. One of these processes, somatic hypermutation (SHM), deposits point mutations into the variable region of the Ig gene to generate higher-affinity variants. Activation-induced cytidine deaminase (AID) converts cytidine to uridine to initiate the hypermutation process. Error-prone versions of DNA repair are believed to then process these lesions into a diverse spectrum of point mutations. We review the current understanding of the molecular mechanisms and regulation of SHM, and also discuss emerging ideas which merit further exploration.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Immunoglobulin heavy variable 1-2P23083Details
Immunoglobulin heavy variable 3-30P01768Details
Immunoglobulin kappa variable 2D-28P01615Details
Immunoglobulin kappa variable 1-17P01599Details
Immunoglobulin lambda variable 3-21P80748Details
Immunoglobulin heavy constant gamma 3P01860Details
Immunoglobulin heavy constant epsilonP01854Details