Paracetamol and ketorolac pharmacokinetics and metabolism at delivery and during postpartum.
Article Details
- CitationCopy to clipboard
Allegaert K, van Calsteren K, Hendrickx S, Kelchtermans J, Smits A, Kulo A, van de Velde M
Paracetamol and ketorolac pharmacokinetics and metabolism at delivery and during postpartum.
Acta Anaesthesiol Belg. 2012;63(3):121-5.
- PubMed ID
- 23397664 [ View in PubMed]
- Abstract
During pregnancy, changes in renal elimination, body composition and metabolic activity occur. Since these important alterations in physiology also affect drug disposition, pregnancy warrants a focused approach. Despite these differences, even commonly administered drugs have not undergone pharmacokinetic evaluation in pregnant women or at delivery. This is also true for analgesics routinely administered by anesthesiologists during pregnancy or at delivery, like intravenous (i.v.) paracetamol or ketorolac. We report on our observations on i.v. paracetamol and ketorolac disposition following cesarean delivery to illustrate the feasibility of such focused studies and the impact of pregnancy on drug disposition. The clinical relevance of these observations are subsequently discussed, and some future research directions are suggested.
DrugBank Data that Cites this Article
- Drug Reactions
Reaction Details
