Cinatrins, a novel family of phospholipase A2 inhibitors. II. Biological activities.

Article Details

Citation

Copy to clipboard

Tanaka K, Itazaki H, Yoshida T

Cinatrins, a novel family of phospholipase A2 inhibitors. II. Biological activities.

J Antibiot (Tokyo). 1992 Jan;45(1):50-5.

PubMed ID

1548189 [ View in PubMed

]

Abstract

Cinatrins A, B and C3 inhibited phospholipase A2 purified from rat platelets in a dose-dependent manner. Cinatrin C3, the most potent component (IC50 70 microM), was noncompetitive with a Ki value of 36 microM. Cinatrins B and C3 also inhibited both porcine pancreas and Naja naja venom phospholipase A2. Inhibition of rat platelet phospholipase A2 by cinatrin C3 was independent of Ca2+ and substrate concentration. Comparison with duramycin, another phospholipase A2 inhibitor, displayed inhibition dependent on substrate concentration when phosphatidylethanolamine was the substrate. These results indicate that the inhibition of phospholipase A2 by cinatrin C3 may result from direct interaction with the enzyme.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Lancovutide	Cytosolic phospholipase A2	Protein	Humans	Unknown	Inhibitor	Details